Insulin Signaling
Insulin → IR → IRS-1 → PI3K → AKT → GLUT4 translocation.
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flowchart LR
Ins[Insulin] --> IR[Insulin receptor\nphosphorylated]
IR --> IRS[IRS-1]
IRS --> PI3K[PI3K]
PI3K --> PIP3[PIP3]
PIP3 --> PDK1[PDK1]
PDK1 --> AKT[AKT / PKB]
AKT --> AS160[AS160 inhibited]
AS160 -.-> GLUT4[GLUT4 vesicles]
GLUT4 --> Mem[Plasma membrane]
Mem --> Up[Glucose uptake]
AKT --> GSK3[GSK3 inhibited] --> Glyc[Glycogen synthesis ↑]