MAPK Signaling Cascade

digraph mapk {
  rankdir=TB;
  graph [bgcolor=transparent];
  node [shape=ellipse, style=filled, fontname=Inter, fontsize=10];

  Lig [label="Ligand\n(e.g. EGF)", fillcolor="#dbeafe"];
  RTK [label="RTK", fillcolor="#dbeafe"];
  Grb [label="Grb2-Sos"];
  Ras [label="Ras-GTP", fillcolor="#fef3c7"];
  Raf [label="Raf"];
  MEK [label="MEK"];
  ERK [label="ERK", fillcolor="#dcfce7"];
  Elk [label="Elk-1 (nucleus)", fillcolor="#fce7f3", shape=box];
  Cyc [label="cyclin D1 (proliferation)", fillcolor="#fce7f3", shape=box];

  Lig -> RTK -> Grb -> Ras -> Raf -> MEK -> ERK;
  ERK -> Elk;
  ERK -> Cyc;
}