PK/PD Model
Two-compartment PK with sigmoid Emax PD link.
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flowchart LR
Dose[Dose / infusion] --> Abs[Absorption\nka]
Abs --> Central[(Central compartment)]
Central --> Periph[(Peripheral compartment)]
Periph --> Central
Central -->|CL| Elim[Elimination]
Central --> Effect["Effect site<br/>(biophase)"]
Effect --> PD["Sigmoid Emax<br/>E = E_max · C^γ / (EC50^γ + C^γ)"]
PD --> Resp[Response]
classDef pk fill:#dbeafe,stroke:#1e3a8a;
classDef pd fill:#fce7f3,stroke:#9d174d;
class Abs,Central,Periph,Elim pk
class Effect,PD,Resp pd