Biology — CRISPR-Cas9 Mechanism

{
  "elements":[
    {"data":{"id":"guide","label":"Guide RNA"}},
    {"data":{"id":"cas9","label":"Cas9 nuclease"}},
    {"data":{"id":"complex","label":"Cas9-gRNA complex"}},
    {"data":{"id":"target","label":"Matches target DNA (PAM)"}},
    {"data":{"id":"cut","label":"Double-strand break"}},
    {"data":{"id":"nhej","label":"NHEJ -> knockout"}},
    {"data":{"id":"hdr","label":"HDR -> precise edit"}},
    {"data":{"source":"guide","target":"complex"}},
    {"data":{"source":"cas9","target":"complex"}},
    {"data":{"source":"complex","target":"target"}},
    {"data":{"source":"target","target":"cut"}},
    {"data":{"source":"cut","target":"nhej"}},
    {"data":{"source":"cut","target":"hdr"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}