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Medicine — Drug Metabolism

Phase I and II hepatic drug processing.

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{
  "elements":[
    {"data":{"id":"drug","label":"Lipophilic drug"}},
    {"data":{"id":"p1","label":"Phase I (CYP450)"}},
    {"data":{"id":"inter","label":"Reactive intermediate"}},
    {"data":{"id":"p2","label":"Phase II (conjugation)"}},
    {"data":{"id":"polar","label":"Water-soluble metabolite"}},
    {"data":{"id":"excrete","label":"Excretion (urine/bile)"}},
    {"data":{"source":"drug","target":"p1","label":"oxidation"}},
    {"data":{"source":"p1","target":"inter"}},
    {"data":{"source":"inter","target":"p2","label":"+glucuronide"}},
    {"data":{"source":"p2","target":"polar"}},
    {"data":{"source":"polar","target":"excrete"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}