Medicine — Drug Metabolism
Phase I and II hepatic drug processing.
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{
"elements":[
{"data":{"id":"drug","label":"Lipophilic drug"}},
{"data":{"id":"p1","label":"Phase I (CYP450)"}},
{"data":{"id":"inter","label":"Reactive intermediate"}},
{"data":{"id":"p2","label":"Phase II (conjugation)"}},
{"data":{"id":"polar","label":"Water-soluble metabolite"}},
{"data":{"id":"excrete","label":"Excretion (urine/bile)"}},
{"data":{"source":"drug","target":"p1","label":"oxidation"}},
{"data":{"source":"p1","target":"inter"}},
{"data":{"source":"inter","target":"p2","label":"+glucuronide"}},
{"data":{"source":"p2","target":"polar"}},
{"data":{"source":"polar","target":"excrete"}}
],
"layout":{"name":"breadthfirst","directed":true}
}