Biology — TGF-β / SMAD Pathway

TGF-β signalling through receptor SMADs to the nucleus.

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{
  "elements":[
    {"data":{"id":"tgf","label":"TGF-β"}},
    {"data":{"id":"rec","label":"Type I/II receptors"}},
    {"data":{"id":"rsmad","label":"R-SMAD (2/3)"}},
    {"data":{"id":"smad4","label":"SMAD4"}},
    {"data":{"id":"complex","label":"SMAD complex"}},
    {"data":{"id":"genes","label":"Target genes"}},
    {"data":{"source":"tgf","target":"rec"}},
    {"data":{"source":"rec","target":"rsmad","label":"phosphorylate"}},
    {"data":{"source":"rsmad","target":"complex"}},
    {"data":{"source":"smad4","target":"complex"}},
    {"data":{"source":"complex","target":"genes"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}