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Drug-interaction network templates

Biology — Azole Antifungal Interactions

Potent CYP3A4 inhibition by azole antifungals.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Azole antifungal interactionsCYP3A4 inhibitionrhabdomyolysisCYP2C9/3A4 inhibitionrise in INRCYP3A4 inhibitionrise in levelsblocked metabolismQT prolongationKetoconazoleantifungalSimvastatinstatinWarfarinanticoagulantCiclosporinimmunosuppressantTerfenadineantihistamineminormoderatemajorcontraindicated

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title "Azole antifungal interactions"
drug K "Ketoconazole" class antifungal
drug S "Simvastatin"  class statin
drug W "Warfarin"     class anticoagulant
drug C "Ciclosporin"  class immunosuppressant
drug T "Terfenadine"  class antihistamine

interact K S "rhabdomyolysis" severity major mechanism "CYP3A4 inhibition"
interact K W "rise in INR" severity major mechanism "CYP2C9/3A4 inhibition"
interact K C "rise in levels" severity major mechanism "CYP3A4 inhibition"
interact K T "QT prolongation" severity contraindicated mechanism "blocked metabolism"