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Genetics pedigree templates

Biology — Pedigree: Tay-Sachs (AR)

Autosomal recessive lysosomal storage disease.

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Tay-Sachs disease (autosomal recessive)I1I2II1II2II3Unaffected maleUnaffected femaleAffectedCarrierConsistent with 2 modes — autosomal recessive, X-linked recessive.Consistent with 2 modes: autosomal recessive, X-linked recessive. The other 4 modes are refuted — aut…Autosomal dominant is ruled out: II1 is affected and neither parent is. Under a dominant mode one cop…X-linked dominant is ruled out: II1 is affected and neither parent is, which a dominant mode cannot p…Mitochondrial is ruled out: II1 is affected and their mother I2 is not. Mitochondria come from the eg…Y-linked is ruled out: II1 is affected and his father I1 is not, and a son's Y chromosome comes from …

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title "Tay-Sachs disease (autosomal recessive)"
individual I1 sex male affected no carrier yes gen 1
individual I2 sex female affected no carrier yes gen 1
mating I1 I2
individual II1 sex male affected yes gen 2 parents I1 I2
individual II2 sex female affected no carrier yes gen 2 parents I1 I2
individual II3 sex female affected no gen 2 parents I1 I2