Vesicle Trafficking

digraph vt {
  rankdir=LR;
  graph [bgcolor=transparent];
  node [shape=ellipse, style=filled, fillcolor="#dbeafe", fontname=Inter, fontsize=10];

  ER [label="Rough ER\n(synthesis)", fillcolor="#fef3c7"];
  Cop2 [label="COPII vesicles"];
  Golgi [label="Golgi apparatus", fillcolor="#dcfce7"];
  Cop1 [label="COPI vesicles\n(retrograde)"];
  TGN [label="trans-Golgi\nnetwork"];
  Sec [label="Secretory vesicle"];
  PM [label="Plasma membrane", fillcolor="#fce7f3"];
  Endo [label="Endosome", fillcolor="#ede9fe"];
  Lyso [label="Lysosome", fillcolor="#fee2e2"];

  ER -> Cop2 -> Golgi -> TGN -> Sec -> PM;
  Golgi -> Cop1 -> ER;
  PM -> Endo [label="endocytosis (clathrin)"];
  Endo -> Lyso [label="degradation"];
  Endo -> PM [label="recycling"];
  TGN -> Lyso [label="hydrolases"];
}