Enzyme Catalysis Cycle

E + S → ES → ES* → EP → E + P, the canonical enzyme cycle.

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digraph enz {
  layout=circo;
  graph [bgcolor=transparent];
  node [shape=box, style="rounded,filled", fontname=Inter, fontsize=10, fillcolor="#dbeafe"];

  ES [label="E·S"];
  EST [label="E·S‡\n(transition state)", fillcolor="#fef3c7"];
  EP [label="E·P"];
  E [label="E", fillcolor="#dcfce7"];
  S [label="+ S", fillcolor="#dcfce7", shape=plain, fillcolor="transparent"];
  P [label="+ P", fillcolor="#fce7f3", shape=plain, fillcolor="transparent"];

  E -> ES [label="substrate binds"];
  ES -> EST [label="activation"];
  EST -> EP [label="bond change"];
  EP -> E [label="product release"];
}