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Drug-interaction network templates

Drug-interactions — HIV antiretrovirals

Boosted protease inhibitors with common co-administered drugs.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
ART interactions (PI-boosted)CYP3A4 inhibition↑ statin exposure↑ statin exposureCYP3A4 induction↓ ART exposure↓ ART exposure↑ tenofovir exposureRitonavirPI boosterLopinavirPIAtorvastatinstatinCarbamazepineanticonvulsantTenofovirNRTIminormoderatemajorcontraindicated

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title "ART interactions (PI-boosted)"
drug R "Ritonavir"      class PI booster
drug L "Lopinavir"      class PI
drug A "Atorvastatin"   class statin
drug C "Carbamazepine"  class anticonvulsant
drug T "Tenofovir"      class NRTI

interact R A "↑ statin exposure"        severity major          mechanism "CYP3A4 inhibition"
interact L A "↑ statin exposure"        severity major
interact R C "↓ ART exposure"           severity major          mechanism "CYP3A4 induction"
interact L C "↓ ART exposure"           severity major
interact L T "↑ tenofovir exposure"     severity moderate