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Drug-interaction network templates

Drug-interactions — Statin metabolism

CYP3A4-mediated statin / antifungal / macrolide interactions.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Statin CYP3A4 interactionsCYP3A4 inhibition↑ myopathy / rhabdoCYP3A4 inhibition↑ myopathy risk↑ myopathy / rhabdo↑ exposureintestinal CYP3A4↑ exposure↑ exposureAtorvastatinstatinSimvastatinstatinClarithromycinmacrolideItraconazoleantifungalGrapefruitCYP3A4 inhibitorminormoderatemajorcontraindicated

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title "Statin CYP3A4 interactions"
drug A "Atorvastatin"   class statin
drug S "Simvastatin"    class statin
drug C "Clarithromycin" class macrolide
drug I "Itraconazole"   class antifungal
drug G "Grapefruit"     class CYP3A4 inhibitor

interact S C "↑ myopathy / rhabdo" severity contraindicated mechanism "CYP3A4 inhibition"
interact A C "↑ myopathy risk"     severity major           mechanism "CYP3A4 inhibition"
interact S I "↑ myopathy / rhabdo" severity contraindicated
interact A I "↑ exposure"          severity major
interact S G "↑ exposure"          severity major           mechanism "intestinal CYP3A4"
interact A G "↑ exposure"          severity moderate