Host–pathogen model — exposure, burden and response

A conceptual infection-study map distinguishes exposure, pathogen burden, host response and damage. Use appropriate containment and approved protocols; this template specifies measurements rather than operational pathogen-handling steps.

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{
  "nodes": [
    { "id": "host", "type": "rounded", "label": "Host model and baseline", "x": 40, "y": 200, "width": 150, "height": 104, "fill": "#ede9fe", "stroke": "#6d28d9" },
    { "id": "exp", "type": "rounded", "label": "Defined exposure groups", "x": 215, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "mock", "type": "octagon", "label": "Unexposed control", "x": 215, "y": 520, "width": 150, "height": 104, "fill": "#e0f2fe", "stroke": "#0369a1" },
    { "id": "bur", "type": "card", "label": "Pathogen burden readout", "x": 390, "y": 40, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" },
    { "id": "imm", "type": "card", "label": "Host response readout", "x": 390, "y": 360, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" },
    { "id": "dam", "type": "card", "label": "Tissue damage readout", "x": 565, "y": 200, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" },
    { "id": "time", "type": "octagon", "label": "Matched sampling times", "x": 565, "y": 520, "width": 150, "height": 104, "fill": "#e0f2fe", "stroke": "#0369a1" },
    { "id": "assoc", "type": "rounded", "label": "Relate burden and response", "x": 740, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "lim", "type": "rounded", "label": "Model-specific conclusions", "x": 915, "y": 200, "width": 150, "height": 104, "fill": "#f1f5f9", "stroke": "#475569" }
  ],
  "edges": [
    { "id": "e0", "source": "host", "target": "exp", "label": "compare" },
    { "id": "e1", "source": "host", "target": "mock", "label": "baseline control" },
    { "id": "e2", "source": "exp", "target": "bur", "label": "measure" },
    { "id": "e3", "source": "exp", "target": "imm", "label": "measure" },
    { "id": "e4", "source": "bur", "target": "dam", "label": "test relationship" },
    { "id": "e5", "source": "imm", "target": "dam", "label": "test relationship" },
    { "id": "e6", "source": "mock", "target": "dam", "label": "background" },
    { "id": "e7", "source": "time", "target": "assoc", "label": "temporal alignment", "style": "dashed" },
    { "id": "e8", "source": "bur", "target": "assoc", "label": "burden" },
    { "id": "e9", "source": "imm", "target": "assoc", "label": "response" },
    { "id": "e10", "source": "dam", "target": "assoc", "label": "outcome" },
    { "id": "e11", "source": "assoc", "target": "lim", "label": "avoid causal overclaim" }
  ]
}