Immune memory — primary and recall responses
Compare primary activation, contraction and recall in a conceptual immune-response model. Antibody titres, memory-cell frequencies and functional protection are separate readouts and should not be treated as interchangeable.
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{
"nodes": [
{ "id": "naive", "type": "rounded", "label": "Naive antigen-specific cells", "x": 40, "y": 200, "width": 150, "height": 104, "fill": "#dcfce7", "stroke": "#15803d" },
{ "id": "enc", "type": "rounded", "label": "Initial antigen encounter", "x": 215, "y": 200, "width": 150, "height": 104, "fill": "#ede9fe", "stroke": "#6d28d9" },
{ "id": "eff", "type": "rounded", "label": "Effector expansion", "x": 390, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
{ "id": "con", "type": "rounded", "label": "Contraction phase", "x": 565, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
{ "id": "mem", "type": "cylinder", "label": "Memory populations", "x": 740, "y": 200, "width": 150, "height": 104, "fill": "#dbeafe", "stroke": "#1d4ed8" },
{ "id": "rec", "type": "rounded", "label": "Later antigen encounter", "x": 740, "y": 520, "width": 150, "height": 104, "fill": "#ede9fe", "stroke": "#6d28d9" },
{ "id": "resp", "type": "rounded", "label": "Recall response", "x": 915, "y": 200, "width": 150, "height": 104, "fill": "#fce7f3", "stroke": "#be185d" },
{ "id": "tit", "type": "card", "label": "Antibody titre readout", "x": 390, "y": 520, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" },
{ "id": "fun", "type": "card", "label": "Functional protection assay", "x": 915, "y": 520, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" }
],
"edges": [
{ "id": "e0", "source": "naive", "target": "enc", "label": "recognition" },
{ "id": "e1", "source": "enc", "target": "eff", "label": "activation" },
{ "id": "e2", "source": "eff", "target": "con", "label": "resolution" },
{ "id": "e3", "source": "con", "target": "mem", "label": "persistence" },
{ "id": "e4", "source": "mem", "target": "resp", "label": "rapid response" },
{ "id": "e5", "source": "rec", "target": "resp", "label": "restimulation" },
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{ "id": "e8", "source": "tit", "target": "fun", "label": "test relationship", "style": "dashed" }
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}