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Biology — Apoptosis Pathways

Intrinsic and extrinsic routes to programmed cell death.

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{
  "elements":[
    {"data":{"id":"death","label":"Death receptor"}},
    {"data":{"id":"c8","label":"Caspase-8"}},
    {"data":{"id":"mito","label":"Mitochondrion"}},
    {"data":{"id":"cytc","label":"Cytochrome c"}},
    {"data":{"id":"apaf","label":"Apoptosome"}},
    {"data":{"id":"c9","label":"Caspase-9"}},
    {"data":{"id":"c3","label":"Caspase-3"}},
    {"data":{"id":"death2","label":"Cell death"}},
    {"data":{"source":"death","target":"c8","label":"extrinsic"}},
    {"data":{"source":"mito","target":"cytc","label":"intrinsic"}},
    {"data":{"source":"cytc","target":"apaf"}},
    {"data":{"source":"apaf","target":"c9"}},
    {"data":{"source":"c8","target":"c3"}},
    {"data":{"source":"c9","target":"c3"}},
    {"data":{"source":"c3","target":"death2"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}