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Biology — Immune Checkpoint (PD-1)

How tumours exploit PD-1, and how inhibitors release the brake.

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{
  "elements":[
    {"data":{"id":"tcell","label":"T cell"}},
    {"data":{"id":"pd1","label":"PD-1 receptor"}},
    {"data":{"id":"pdl1","label":"PD-L1 on tumour"}},
    {"data":{"id":"inhibit","label":"T cell inhibited"}},
    {"data":{"id":"escape","label":"Tumour escapes immunity"}},
    {"data":{"id":"drug","label":"Checkpoint inhibitor"}},
    {"data":{"id":"attack","label":"T cell attacks tumour"}},
    {"data":{"source":"tcell","target":"pd1"}},
    {"data":{"source":"pdl1","target":"pd1"}},
    {"data":{"source":"pd1","target":"inhibit"}},
    {"data":{"source":"inhibit","target":"escape"}},
    {"data":{"source":"drug","target":"pd1","label":"blocks"}},
    {"data":{"source":"drug","target":"attack"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}