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Drug-interaction network templates

Biology — Macrolide Interactions

CYP3A4 inhibition and QT risk with macrolides.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Macrolide interactionsCYP3A4 inhibitionrhabdomyolysisrise in INRgut flora / P-gpdigoxin toxicityQT prolongationClarithromycinantibioticSimvastatinstatinWarfarinanticoagulantDigoxincardiac-glycosideQT drugantiarrhythmicminormoderatemajorcontraindicated

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title "Macrolide interactions"
drug C "Clarithromycin" class antibiotic
drug S "Simvastatin"    class statin
drug W "Warfarin"       class anticoagulant
drug D "Digoxin"        class cardiac-glycoside
drug Q "QT drug"        class antiarrhythmic

interact C S "rhabdomyolysis" severity major mechanism "CYP3A4 inhibition"
interact C W "rise in INR" severity major
interact C D "digoxin toxicity" severity moderate mechanism "gut flora / P-gp"
interact C Q "QT prolongation" severity major