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Drug-interaction network templates

Biology — Migraine Drug Interactions

Serotonergic and vasoconstrictor interactions.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Migraine medication interactionsserotonin syndromeadditive vasoconstrictionvasospasmserotonin syndromevasospasmMAO-A competition↑ triptan exposure — halve the rizatriptan dosebeta-blockade removes vasodilator tone↑ peripheral vasoconstrictionTriptanantimigraineSSRIantidepressantErgotamineantimigraineMAOIantidepressantPropranololbeta-blockerminormoderatemajorcontraindicated

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title "Migraine medication interactions"
drug T "Triptan"     class antimigraine
drug S "SSRI"        class antidepressant
drug E "Ergotamine"  class antimigraine
drug M "MAOI"        class antidepressant
drug P "Propranolol" class beta-blocker

interact T S "serotonin syndrome" severity major
interact T E "vasospasm" severity major mechanism "additive vasoconstriction"
interact T M "serotonin syndrome" severity major
interact E M "vasospasm" severity major
interact T P "↑ triptan exposure — halve the rizatriptan dose" severity moderate mechanism "MAO-A competition"
interact E P "↑ peripheral vasoconstriction" severity moderate mechanism "beta-blockade removes vasodilator tone"