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Drug-interaction network templates

Biology — Antipsychotic Interactions

Clozapine-centred interactions in schizophrenia.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Antipsychotic interactionsadditive sedationrespiratory arrestCYP1A2 inductionlower clozapine levelsCYP1A2 inhibitionraised clozapine levelsconstipation / ileusClozapineantipsychoticBenzodiazepinesedativeSmokinginducerFluvoxamineantidepressantAnticholinergicanticholinergicminormoderatemajorcontraindicated

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title "Antipsychotic interactions"
drug C "Clozapine"       class antipsychotic
drug B "Benzodiazepine"  class sedative
drug S "Smoking"         class inducer
drug F "Fluvoxamine"     class antidepressant
drug A "Anticholinergic" class anticholinergic

interact C B "respiratory arrest" severity major mechanism "additive sedation"
interact C S "lower clozapine levels" severity moderate mechanism "CYP1A2 induction"
interact C F "raised clozapine levels" severity major mechanism "CYP1A2 inhibition"
interact C A "constipation / ileus" severity moderate