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Drug-interaction network templates

Biology — Tuberculosis Regimen Interactions

Hepatotoxicity and enzyme induction in TB therapy.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Anti-TB drug interactionsadditive liver injuryhepatotoxicityhepatotoxicityCYP inductionfall in INRCYP3A4 inductionloss of efficacyRifampicinantibioticIsoniazidantibioticPyrazinamideantibioticWarfarinanticoagulantOral contraceptivecontraceptiveminormoderatemajorcontraindicated

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title "Anti-TB drug interactions"
drug R "Rifampicin"  class antibiotic
drug I "Isoniazid"   class antibiotic
drug P "Pyrazinamide" class antibiotic
drug W "Warfarin"    class anticoagulant
drug O "Oral contraceptive" class contraceptive

interact R I "hepatotoxicity" severity major mechanism "additive liver injury"
interact I P "hepatotoxicity" severity major
interact R W "fall in INR" severity major mechanism "CYP induction"
interact R O "loss of efficacy" severity major mechanism "CYP3A4 induction"