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Causal DAG templates

Causal DAG — Statin Adherence and Mortality

Confounding structure for an observational study of statin adherence and cardiovascular mortality, with healthy-adherer behaviour as the unmeasured common cause the analysis must address.

Template previewCausal DAG
Statin adherence and cardiovascular mortalityAStatin adherenceYCardiovascular mortalityCBaseline cardiovascular riskDDeprivation indexLAchieved LDL cholesterolHHealthy-adherer behaviourPPolypharmacy burdenGGP continuity of careExposureOutcomeConfounderMediatorUnobservedNo adjustment set works — but `GP continuity of care` is an instrument, which identifies the effect under the usual instrumental-variable assu…No adjustment set works here — and `GP continuity of care` is an INSTRUMENT given `Deprivation index`: it moves the exposure, and this diagram gives it no path to…

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title "Statin adherence and cardiovascular mortality"
exposure A "Statin adherence"
outcome Y "Cardiovascular mortality"
confounder C "Baseline cardiovascular risk"
confounder D "Deprivation index"
mediator L "Achieved LDL cholesterol"
unobserved H "Healthy-adherer behaviour"
node P "Polypharmacy burden"
node G "GP continuity of care"
A -> L
L -> Y
C -> A
C -> Y
C -> L
D -> A
D -> Y
D -> G
G -> A
H -> A
H -> Y
P -> A
P -> Y
C -> P