Apoptosis — Intrinsic + Extrinsic

digraph apop {
  rankdir=TB;
  graph [bgcolor=transparent];
  node [shape=box, style="rounded,filled", fontname=Inter, fontsize=10, fillcolor="#dbeafe"];

  Ext [label="Death receptor\n(FasL, TNF)", fillcolor="#fce7f3"];
  Casp8 [label="Caspase-8"];
  Stress [label="DNA damage / stress", fillcolor="#fef3c7"];
  Bax [label="Bax / Bak"];
  Mito [label="Mitochondria — MOMP", fillcolor="#fef3c7"];
  Cyto [label="Cytochrome c"];
  Casp9 [label="Caspase-9"];
  Casp37 [label="Executioner caspases\n3 / 6 / 7", fillcolor="#dcfce7"];
  Death [label="Apoptosis", fillcolor="#fee2e2"];

  Ext -> Casp8 -> Casp37;
  Stress -> Bax -> Mito -> Cyto -> Casp9 -> Casp37 -> Death;
  Casp8 -> Bax [label="Bid cleavage", style=dashed];
}