Clinical Trial Phases

{
  "nodes": [
    { "id":"pre","type":"rect","label":"Preclinical\n(in vitro / animal)","x":40,"y":160,"fill":"#dbeafe" },
    { "id":"p1","type":"rect","label":"Phase I\nSafety, dose (20–80)","x":240,"y":160,"fill":"#dcfce7" },
    { "id":"p2","type":"rect","label":"Phase II\nEfficacy signal (100–300)","x":440,"y":160,"fill":"#dcfce7" },
    { "id":"p3","type":"rect","label":"Phase III\nRCT, regulatory (1,000+)","x":640,"y":160,"fill":"#fef3c7" },
    { "id":"app","type":"diamond","label":"Approval","x":840,"y":145,"fill":"#fef3c7" },
    { "id":"p4","type":"rect","label":"Phase IV\nPost-market surveillance","x":1040,"y":160,"fill":"#fce7f3" }
  ],
  "edges": [
    { "id":"e1","source":"pre","target":"p1","label":"IND" },
    { "id":"e2","source":"p1","target":"p2","label":"safe" },
    { "id":"e3","source":"p2","target":"p3","label":"signal" },
    { "id":"e4","source":"p3","target":"app","label":"NDA/BLA" },
    { "id":"e5","source":"app","target":"p4","label":"approved" }
  ]
}