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Drug-interaction network templates

Drug-interactions — Warfarin polypharmacy

Classic anticoagulant interaction map (Warfarin, Amiodarone, NSAIDs, Aspirin).

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
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Warfarin polypharmacyCYP2C9 / 3A4 inhibition↑ INR↑ bleedingdisplaces plasma binding↑ bleedingCYP2C9 inhibition↑ INR↑ bleedingWarfarinanticoagulantAmiodaroneantiarrhythmicAspirinantiplateletIbuprofenNSAIDFluconazoleantifungalminormoderatemajorcontraindicated

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title "Warfarin polypharmacy"
drug W "Warfarin"     class anticoagulant
drug A "Amiodarone"   class antiarrhythmic
drug S "Aspirin"      class antiplatelet
drug I "Ibuprofen"    class NSAID
drug F "Fluconazole"  class antifungal

interact W A "↑ INR"          severity major   mechanism "CYP2C9 / 3A4 inhibition"
interact W S "↑ bleeding"     severity major
interact W I "↑ bleeding"     severity major   mechanism "displaces plasma binding"
interact W F "↑ INR"          severity major   mechanism "CYP2C9 inhibition"
interact A S "↑ bleeding"     severity moderate