Receptor signalling — response and adaptation

A generic receptor-signalling model distinguishes ligand binding, signal amplification and termination. Feedback and receptor trafficking can alter response duration; arrows specify regulation rather than material transfer.

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{
  "nodes": [
    { "id": "lig", "type": "rounded", "label": "Extracellular ligand", "x": 40, "y": 200, "width": 150, "height": 104, "fill": "#ede9fe", "stroke": "#6d28d9" },
    { "id": "rec", "type": "rounded", "label": "Ligand-bound receptor", "x": 215, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "relay", "type": "rounded", "label": "Intracellular relay", "x": 390, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "eff", "type": "rounded", "label": "Effector response", "x": 565, "y": 200, "width": 150, "height": 104, "fill": "#fce7f3", "stroke": "#be185d" },
    { "id": "fb", "type": "octagon", "label": "Induced negative regulator", "x": 565, "y": 520, "width": 150, "height": 104, "fill": "#e0f2fe", "stroke": "#0369a1" },
    { "id": "int", "type": "rounded", "label": "Receptor internalisation", "x": 215, "y": 520, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "recy", "type": "rounded", "label": "Recycling / degradation", "x": 40, "y": 520, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "off", "type": "rounded", "label": "Signal termination", "x": 740, "y": 200, "width": 150, "height": 104, "fill": "#fef3c7", "stroke": "#b45309" },
    { "id": "dur", "type": "card", "label": "Amplitude and duration readouts", "x": 915, "y": 200, "width": 150, "height": 104, "fill": "#ccfbf1", "stroke": "#0f766e" }
  ],
  "edges": [
    { "id": "e0", "source": "lig", "target": "rec", "label": "binding" },
    { "id": "e1", "source": "rec", "target": "relay", "label": "activates" },
    { "id": "e2", "source": "relay", "target": "eff", "label": "transduces" },
    { "id": "e3", "source": "eff", "target": "fb", "label": "induces" },
    { "id": "e4", "source": "fb", "target": "relay", "label": "attenuates", "style": "dashed" },
    { "id": "e5", "source": "rec", "target": "int", "label": "trafficking" },
    { "id": "e6", "source": "int", "target": "recy", "label": "sorting" },
    { "id": "e7", "source": "recy", "target": "rec", "label": "recycling fraction", "style": "dashed" },
    { "id": "e8", "source": "relay", "target": "off", "label": "deactivation" },
    { "id": "e9", "source": "eff", "target": "dur", "label": "measure" },
    { "id": "e10", "source": "off", "target": "dur", "label": "measure decay" }
  ]
}