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Biology — Ferroptosis

Iron-dependent cell death by lipid peroxidation.

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{
  "elements":[
    {"data":{"id":"iron","label":"Iron accumulation"}},
    {"data":{"id":"ros","label":"Lipid ROS"}},
    {"data":{"id":"pufa","label":"PUFA peroxidation"}},
    {"data":{"id":"gpx4","label":"GPX4 (normally protects)"}},
    {"data":{"id":"membrane","label":"Membrane damage"}},
    {"data":{"id":"death","label":"Ferroptotic cell death"}},
    {"data":{"source":"iron","target":"ros"}},
    {"data":{"source":"ros","target":"pufa"}},
    {"data":{"source":"gpx4","target":"ros","label":"inhibits"}},
    {"data":{"source":"pufa","target":"membrane"}},
    {"data":{"source":"membrane","target":"death"}}
  ],
  "layout":{"name":"breadthfirst","directed":true}
}