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Drug-interaction network templates

Biology — Antiretroviral (HIV) Interactions

Boosted protease inhibitors and CYP-mediated interactions.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Antiretroviral interactionsCYP3A4 inhibitionrhabdomyolysisCYP3A4 inhibitiondeep sedationintended boostingboosted levelsCYP3A4 inductionloss of efficacyRitonavirprotease-inhibitorAtazanavirprotease-inhibitorSimvastatinstatinRifampicinantibioticMidazolamsedativeminormoderatemajorcontraindicated

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title "Antiretroviral interactions"
drug R "Ritonavir"    class protease-inhibitor
drug A "Atazanavir"   class protease-inhibitor
drug S "Simvastatin"  class statin
drug F "Rifampicin"   class antibiotic
drug M "Midazolam"    class sedative

interact R S "rhabdomyolysis" severity contraindicated mechanism "CYP3A4 inhibition"
interact R M "deep sedation" severity major mechanism "CYP3A4 inhibition"
interact R A "boosted levels" severity moderate mechanism "intended boosting"
interact A F "loss of efficacy" severity major mechanism "CYP3A4 induction"