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Drug-interaction network templates

Biology — Proton Pump Inhibitor Interactions

Absorption and antiplatelet interactions with PPIs.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
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Proton pump inhibitor interactionsCYP2C19 inhibitionreduced antiplatelet effectneeds acidreduced absorptionreduced absorptionraised MTX levelsPPI (omeprazole)antacidClopidogrelantiplateletKetoconazoleantifungalIron / B12supplementMethotrexateantimetaboliteminormoderatemajorcontraindicated

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title "Proton pump inhibitor interactions"
drug P "PPI (omeprazole)" class antacid
drug C "Clopidogrel"      class antiplatelet
drug K "Ketoconazole"     class antifungal
drug I "Iron / B12"       class supplement
drug M "Methotrexate"     class antimetabolite

interact P C "reduced antiplatelet effect" severity moderate mechanism "CYP2C19 inhibition"
interact P K "reduced absorption" severity moderate mechanism "needs acid"
interact P I "reduced absorption" severity minor
interact P M "raised MTX levels" severity moderate