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Drug-interaction network templates

Biology — Antiepileptic Interactions

Enzyme induction and inhibition among anticonvulsants.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Antiepileptic interactionsglucuronidation inhibitionrise in levelsmutual inductionaltered levelsCYP inductionaltered INRCYP3A4 inductionfall in INRPhenytoinantiepilepticCarbamazepineantiepilepticValproateantiepilepticLamotrigineantiepilepticWarfarinanticoagulantminormoderatemajorcontraindicated

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title "Antiepileptic interactions"
drug P "Phenytoin"     class antiepileptic
drug C "Carbamazepine" class antiepileptic
drug V "Valproate"     class antiepileptic
drug L "Lamotrigine"   class antiepileptic
drug W "Warfarin"      class anticoagulant

interact V L "rise in levels" severity major mechanism "glucuronidation inhibition"
interact C P "altered levels" severity moderate mechanism "mutual induction"
interact P W "altered INR" severity major mechanism "CYP induction"
interact C W "fall in INR" severity major mechanism "CYP3A4 induction"