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Drug-interaction network templates

Biology — Chemotherapy Interactions

Overlapping toxicities among cytotoxic agents.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Chemotherapy interactionsadditive renal injurynephro/ototoxicityreduced clearancerise in MTX toxicityadditive myelotoxicitymarrow suppressioncardiotoxicity riskCisplatinalkylatingDoxorubicinanthracyclineMethotrexateantimetaboliteVincristinevinca-alkaloidAminoglycosideantibioticminormoderatemajorcontraindicated

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title "Chemotherapy interactions"
drug C "Cisplatin"     class alkylating
drug D "Doxorubicin"   class anthracycline
drug M "Methotrexate"  class antimetabolite
drug V "Vincristine"   class vinca-alkaloid
drug A "Aminoglycoside" class antibiotic

interact C A "nephro/ototoxicity" severity major mechanism "additive renal injury"
interact C M "rise in MTX toxicity" severity major mechanism "reduced clearance"
interact D V "marrow suppression" severity moderate mechanism "additive myelotoxicity"
interact C D "cardiotoxicity risk" severity moderate