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Drug-interaction network templates

Biology — Methotrexate Interactions

Drugs that raise methotrexate toxicity.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Methotrexate interactionsreduced renal clearancerise in toxicityadditive antifolatemarrow suppressionreduced excretionrise in levelsreduced clearancerise in toxicityMethotrexateantimetaboliteNSAIDanalgesicTrimethoprimantibioticProton pump inhibitorantacidAspirinantiplateletminormoderatemajorcontraindicated

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title "Methotrexate interactions"
drug M "Methotrexate" class antimetabolite
drug N "NSAID"        class analgesic
drug T "Trimethoprim" class antibiotic
drug P "Proton pump inhibitor" class antacid
drug A "Aspirin"      class antiplatelet

interact M N "rise in toxicity" severity major mechanism "reduced renal clearance"
interact M T "marrow suppression" severity major mechanism "additive antifolate"
interact M P "rise in levels" severity moderate mechanism "reduced excretion"
interact M A "rise in toxicity" severity major mechanism "reduced clearance"