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Drug-interaction network templates

Biology — Renal Triple Whammy

ACE inhibitor + diuretic + NSAID acute kidney injury.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Triple whammy (AKI risk)reduced angiotensin IIefferent dilationvolume depletionreduced prostaglandinafferent constrictioncombined hitacute kidney injuryacute kidney injuryACE inhibitorantihypertensiveDiureticdiureticNSAIDanalgesicKidneyorganminormoderatemajorcontraindicated

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title "Triple whammy (AKI risk)"
drug A "ACE inhibitor" class antihypertensive
drug D "Diuretic"      class diuretic
drug N "NSAID"         class analgesic
drug K "Kidney"        class organ

interact A K "efferent dilation" severity moderate mechanism "reduced angiotensin II"
interact D K "volume depletion" severity moderate
interact N K "afferent constriction" severity moderate mechanism "reduced prostaglandin"
interact A N "acute kidney injury" severity major mechanism "combined hit"
interact D N "acute kidney injury" severity major