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Drug-interaction network templates

Biology — CYP450 Drug Interactions

Interactions mediated by cytochrome-P450 enzymes.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
CYP450-mediated interactionsCYP3A4 inhibition↑ statin (myopathy)CYP2C9 inhibition↑ INR (bleeding)CYP induction↓ warfarin effectCYP3A4 inhibition↑ statin levelsWarfarinanticoagulantClarithromycinantibioticSimvastatinstatinFluconazoleantifungalRifampicinantibioticminormoderatemajorcontraindicated

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title "CYP450-mediated interactions"
drug W "Warfarin"     class anticoagulant
drug C "Clarithromycin" class antibiotic
drug S "Simvastatin"  class statin
drug F "Fluconazole"  class antifungal
drug R "Rifampicin"   class antibiotic

interact C S "↑ statin (myopathy)" severity major mechanism "CYP3A4 inhibition"
interact F W "↑ INR (bleeding)"    severity major mechanism "CYP2C9 inhibition"
interact R W "↓ warfarin effect"   severity moderate mechanism "CYP induction"
interact F S "↑ statin levels"     severity moderate mechanism "CYP3A4 inhibition"