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Drug-interaction network templates

Biology — Statin Myopathy Risks

CYP3A4 inhibitors that raise statin levels and myopathy risk.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Statin interactionsCYP3A4 inhibitionrise in myopathyCYP3A4 inhibitionrise in myopathygut CYP3A4 inhibitionrise in levelsadditive myotoxicityrhabdomyolysisCYP3A4 inhibitionrise in levelsSimvastatinstatinClarithromycinantibioticAmiodaroneantiarrhythmicGrapefruitfoodFibratelipid-loweringItraconazoleantifungalminormoderatemajorcontraindicated

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title "Statin interactions"
drug S "Simvastatin"   class statin
drug C "Clarithromycin" class antibiotic
drug A "Amiodarone"    class antiarrhythmic
drug G "Grapefruit"    class food
drug F "Fibrate"       class lipid-lowering
drug I "Itraconazole"  class antifungal

interact S C "rise in myopathy" severity major mechanism "CYP3A4 inhibition"
interact S A "rise in myopathy" severity major mechanism "CYP3A4 inhibition"
interact S G "rise in levels" severity moderate mechanism "gut CYP3A4 inhibition"
interact S F "rhabdomyolysis" severity major mechanism "additive myotoxicity"
interact S I "rise in levels" severity major mechanism "CYP3A4 inhibition"