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Drug-interaction network templates

Biology — QT-Prolonging Combinations

Stacking QT-prolonging drugs raises torsades risk.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
QT prolongationadditive hERG blockQT prolongationQT prolongationQT prolongationQT prolongationQT prolongationtorsades riskAmiodaroneantiarrhythmicMacrolideantibioticFluoroquinoloneantibioticHaloperidolantipsychoticOndansetronantiemeticCitalopramantidepressantminormoderatemajorcontraindicated

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title "QT prolongation"
drug A "Amiodarone"    class antiarrhythmic
drug M "Macrolide"     class antibiotic
drug F "Fluoroquinolone" class antibiotic
drug H "Haloperidol"   class antipsychotic
drug O "Ondansetron"   class antiemetic
drug C "Citalopram"    class antidepressant

interact A M "QT prolongation" severity major mechanism "additive hERG block"
interact A H "QT prolongation" severity major
interact M F "QT prolongation" severity moderate
interact H O "QT prolongation" severity moderate
interact C M "QT prolongation" severity moderate
interact A C "torsades risk" severity major