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Drug-interaction network templates

Biology — Warfarin Interactions

Drugs that raise bleeding risk or alter INR on warfarin.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Warfarin polypharmacyCYP2C9 / 3A4 inhibitionrise in INRCYP inhibitionrise in INRrise in bleedinggastric injury + bindingrise in bleedingclotting-factor synthesisfall in INRWarfarinanticoagulantAmiodaroneantiarrhythmicCiprofloxacinantibioticAspirinantiplateletNSAIDanalgesicVitamin Knutrientminormoderatemajorcontraindicated

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title "Warfarin polypharmacy"
drug W "Warfarin"     class anticoagulant
drug A "Amiodarone"   class antiarrhythmic
drug C "Ciprofloxacin" class antibiotic
drug S "Aspirin"      class antiplatelet
drug N "NSAID"        class analgesic
drug K "Vitamin K"    class nutrient

interact W A "rise in INR" severity major mechanism "CYP2C9 / 3A4 inhibition"
interact W C "rise in INR" severity major mechanism "CYP inhibition"
interact W S "rise in bleeding" severity major
interact W N "rise in bleeding" severity major mechanism "gastric injury + binding"
interact W K "fall in INR" severity moderate mechanism "clotting-factor synthesis"