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Drug-interaction network templates

Biology — Digoxin Toxicity

Drugs that raise digoxin levels or potentiate its effect.

Drug-interaction networkLife SciencesDrug-interaction network syntax docs
Template previewDrug-interaction network
Digoxin interactionsP-glycoprotein inhibitionrise in levelsP-gp inhibitionrise in levelshypokalaemiatoxicitydisplaces + P-gprise in levelsDigoxincardiac-glycosideAmiodaroneantiarrhythmicVerapamilcalcium-blockerLoop diureticdiureticQuinidineantiarrhythmicminormoderatemajorcontraindicated

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title "Digoxin interactions"
drug D "Digoxin"      class cardiac-glycoside
drug A "Amiodarone"   class antiarrhythmic
drug V "Verapamil"    class calcium-blocker
drug L "Loop diuretic" class diuretic
drug Q "Quinidine"    class antiarrhythmic

interact D A "rise in levels" severity major mechanism "P-glycoprotein inhibition"
interact D V "rise in levels" severity major mechanism "P-gp inhibition"
interact D L "toxicity" severity major mechanism "hypokalaemia"
interact D Q "rise in levels" severity major mechanism "displaces + P-gp"