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Drug-interaction network templates

Biology — Gout Drug Interactions

Allopurinol and urate-lowering interactions.

Template previewDrug-interaction network
Gout medication interactionsxanthine oxidase blockmarrow suppressionreduced excretionraises urateintended effectlowers urateadditive toxicityAllopurinolurate-loweringAzathioprineimmunosuppressantThiazidediureticUric acidmetaboliteColchicineanti-inflammatoryminormoderatemajorcontraindicated

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title "Gout medication interactions"
drug A "Allopurinol"  class urate-lowering
drug Z "Azathioprine" class immunosuppressant
drug T "Thiazide"     class diuretic
drug U "Uric acid"    class metabolite
drug C "Colchicine"   class anti-inflammatory

interact A Z "marrow suppression" severity major mechanism "xanthine oxidase block"
interact T U "raises urate" severity moderate mechanism "reduced excretion"
interact A U "lowers urate" severity minor mechanism "intended effect"
interact A C "additive toxicity" severity moderate